Chromothriptic
WebSep 24, 2024 · Longitudinal analysis of chromothriptic patterns in 24 matched tumour pairs reveals insights in the clonal evolution of tumours with chromothripsis. The shattering of chromosomes is a dramatic ... WebMay 8, 2024 · Chromothripsis is linked with specific telomere patterns and univocal mutational signatures in distinct tumour entities. Longitudinal analysis of chromothriptic …
Chromothriptic
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WebThe mechanistic basis of the chromothriptic process is unknown, but several nonexclusive models have been proposed. ( a ) The micronuclei hypothesis explains the locally restricted DNA damage. According to this … WebNov 13, 2024 · Chromothripsis is a form of genome instability by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosomes. Widely assumed to be an early event in tumor development, this phenomenon plays a prominent role in tumor onset.
Web开馆时间:周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebIn chromothriptic medulloblastoma, an ecosystem of cells from multiple genetic clones resisting treatment and leading to relapse highlighted the importance of multi-clone interplay. Finally, we identified a potential role for tumour microtubes in treatment resistance in chromothriptic medulloblastoma, suggesting cell network communication as a ...
WebLongitudinal analysis of chromothriptic patterns in 24 matched tumour pairs reveals novel insights in the clonal evolution ... (Show More) Chromothripsis is a recently identified mutational phenomenon, by which a presumably single catastrophic event generates extensive genomic rearrangements of one or a few chromosome(s). WebSemantic Scholar profile for Z. Slámová, with 25 highly influential citations and 11 scientific research papers.
WebChromothripsis is a catastrophic cellular event recently described in cancer in which chromosomes undergo massive deletion and rearrangement. Here, we report a case in …
WebJun 25, 2024 · Chromothripsis is a major event for the formation of double-minute chromosomes Double-minutechromosomes,extrachromosomalcircularDNAfragmentscarryingamplified oncogenes,werepreviouslysuggestedtobegeneratedbychromothripsis2,10buthavenot … the sheglapesWebChromothripsis* Comparative Genomic Hybridization DNA Copy Number Variations Disease Progression Female Humans Kaplan-Meier Estimate Male Middle Aged Multiple … my senior cat drinks a lot of waterWebFeb 9, 2016 · Telomere length and telomere stabilization mechanisms diverge between samples with and without chromothripsis in a given tumor subtype. Longitudinal analyses of the evolution of chromothriptic patterns identify either stable patterns between matched primary and relapsed tumors, or loss of the chromothriptic clone in the relapsed specimen. my senior definitionWebFeb 12, 2015 · DOI: 10.1016/j.cell.2015.01.014 Abstract Chromothripsis is a catastrophic cellular event recently described in cancer in which chromosomes undergo … the sheftall coWebSep 27, 2024 · Chromothripsis is a localised catastrophic genome shattering event that can be used to study how the underlying genomic sequence affects this higher order structuring. Since chromothripsis tends to... my senior cat is always hungryWebNov 15, 2024 · In the vast majority of cases, multiple chromosomes per tumor were affected, with most chromothriptic events on chromosomes 11 and 17 including, among other … my senior dog is not eatingWebMay 28, 2024 · The mutagenic event was independent of specific local DNA motifs or de novo point mutations, but may be driven by spermatogenesis-specific factors. These results indicate that during spermatogenesis, a transient multifocal genomic crisis can introduce several chromothriptic and non-chromothriptic changes into the genome. the shefford great shefford