Cisplatin toxicity review

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August undefined, 2024

WebMar 28, 2024 · This study was conducted to evaluate the renal disease hirsutidin in the paradigm of renal toxicity induced by cisplatin. Male Wistar rats were given cisplatin (3 mg/kg body weight/day, for 25 ... WebThe purpose of the review is to consolidate the reported risk of cardiotoxicity in patients treated with cisplatin based chemotherapy. Cisplatin can induce direct myocardial toxicity leading to atrial fibrillation whereas the potential of myocardial toxicity is amplified when the drug is administered in combination with other cardiotoxic agents.

Toxicity, risk factors and management of cisplatin-induced toxicity: …

WebMar 15, 2024 · Cisplatin is a bedrock of cancer management and one of the most used chemotherapeutic agents in the treatment of germ cell, lung, bladder, ovarian, and head and neck cancers. Approximately 500,000 ... This is a review of cisplatin-induced ototoxicity and strategies to minimize the negative impact on QoL and outcome. WebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin.Renal toxicity has been … norepinephrine and hypovolemic shock

Molecules Free Full-Text Phenethyl Isothiocyanate and Cisplatin …

WebReview on Pharmacology of Cisplatin: Clinical Use, Toxicity and Mechanism of Resistance of Cisplatin Sara A. Aldossary Clinical pharmacy college, king faisal university Alhassa … WebSep 21, 2016 · Cisplatin produced superior response rates and survival in head and neck cancers. There are no published randomized phase III studies of bladder, cervical, endometrial, and esophageal cancers. CONCLUSION: Carboplatin does not possess equivalent activity to cisplatin in all platinum-sensitive tumors. WebSep 27, 2024 · We conducted a systematic review to identify which genetic variants consistently associated with cisplatin-induced nephrotoxicity in oncology patients and assessed whether there are genetic variants that might be clinically relevant to guide cisplatin treatment. Methods how to remove how to simplified

Mechanisms of Cisplatin nephrotoxicity - PubMed

Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD ...

WebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically … WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … norepinephrine alpha beta adrenergic receptorWebApr 5, 2024 · Concurrent chemoradiotherapy with 3-weekly cisplatin 100 mg/m 2 has been the standard of care for locoregionally advanced head and neck cancer (LA-HNC) with level I evidence. While the outcomes in terms of efficacy have been well established, the toxicity profile, compliance, and real-world applicability has been an area of ongoing concern for … how to remove how to simplify ex

"WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. Cisplatin induces ototoxicity, peripheral (most prevalent) and central (rare) neurotoxicity. " - Cisplatin toxicity review

Cisplatin toxicity review

Involvement of cytochrome P450 in cisplatin treatment ... - PubMed

WebIntroduction: Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the treatment of many malignancies. Nephrotoxicity is the primary dose-limiting toxicity, … Webcisplatin-induced nephrotoxicity has not been well studied. Intracellular Events that Damage Renal Cells The in vivo mechanisms of cisplatin nephrotoxic-ity are complex and involve …

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WebOct 5, 2014 · In clinical trials, cisplatin is often selected due to its strong antitumor activity, but its adverse effects include renal toxicity (Iwasaki, Nagata et al., 2005), nausea and … WebMethods: This article examined a collection of studies suggesting that CYP450 enzymes may influence cisplatin toxicity. We performed a narrative mini-review. Results: The studies review showed that CYP450 enzymes have an important role in drug-induced hepatotoxicity and nephrotoxicity, mainly CYP2E1 and CYP4A11.

WebCisplatin has demonstrated efficacy against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. The current study presents a …

WebCisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum analogs, … WebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ...

WebHowever, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major mechanisms of cisplatin-induced renal toxicity involve oxidative stress, inflammation, and renal fibrosis, which are covered in …

WebThe cytotoxic activity in human cancer cell lines against colon adenocarcinoma (HCT-15), mammary adenocarcinoma (MCF-7), and lung adenocarcinoma (SKLU-1) was found comparable ((DAC) 2 Mg), or ca. 2-fold higher ((DAC) 2 Zn) than cisplatin. The acute toxicity assays indicate class 5 toxicity, according to the Organization for Economic Co ... norepinephrine cause bradycardiaWebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the … norepinephrine ati medication templateWebThe major toxicities of a cisplatin overdose include nausea and vomiting, renal insufficiency, electrolyte abnormalities, myelosuppression, ototoxicity, peripheral … norepinephrine and sodium pumpsWebOct 5, 2014 · Furthermore, combination therapies of cisplatin with other drugs have been highly considered to overcome drug-resistance and reduce toxicity. This comprehensive review highlights the physicochemical properties of cisplatin and related platinum-based drugs, and discusses its uses (either alone or in combination with other drugs) for the ... how to remove hoverWebCisplatin, an effective antineoplastic drug used in the treatment of many cancers, has ototoxic potential, thus placing cancer patients, receiving this treatment, at risk of hearing loss. norepinephrine and serotonin depressionWebCisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc. norepinephrine and urine outputWebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. norepinephrine definition medical terminology