Solubility of theophylline in water

Author: tbzy

August undefined, 2024

WebTheophylline (3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione ); anhydrous, ≥ 99%, powder; WebJan 1, 1975 · Melting Range The original synthetic literature27 reported a melting point 0 ; 264O for theophylline subsequently the melting range has been reported to be between 271° and 274O C.28 c Solubility The reported solubility of theophylline is 8.3 mg/ml in water; 12.5 mg/ml in ethanol; 11.f,Tg/ml in , Several chloroform; and sparingly soluble in ...

Pharmaceutics Free Full-Text Compounding Tailored Veterinary ...

WebJun 23, 2009 · The enthalpies of solution $$ \\Updelta_{sol}^{{}} H_{m}^{{}} $$ of polymorphic forms I and II of theophylline in water at 298.15 K using the isoperibol solution calorimeter have been determined in the range of concentration (0.311–1.547) · 10−3 /mol · kg−1. The enthalpies of hydration $$ \\Updelta_{hyd}^{{}} H_{m}^{o} $$ were determined … Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in … graphtec arms test sheet

Theophylline CAS 58-55-9 SCBT - Santa Cruz Biotechnology

WebAug 1, 2024 · The equilibrium solubility of caffeine and theophylline were determined in {methanol + water} binary mixtures at 298.15 K by means of the shaken flask method and … WebC s is the solubility of theophylline and k is the pH of the theophylline solution. The results are shown in Table 4.From the table,it is seen that, the solubility of theophylline increases … WebThe solubility of the compound in water at 30 degrees (0.047 mg/ml) is 180-fold lower than that of theophylline (8.40 mg/ml). The complex is relatively stable in the alkaline pH range, but it hydrolyzes, releasing theophylline in acidic environments. The rate of theophylline release is pH dependent. graphtec anti static kit

Zn(II)-theophylline-ethylenediamine: structure and pH stability

WebTheophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4.* (phosphoric … WebAminophylline is soluble in water and insoluble in alcohol. Theophylline occurs as bitter-tasting, odorless, white, crystalline powder with a melting point between 270-274°C. It is sparingly soluble in alcohol and only slightly soluble in water at a pH of 7, but solubility increases with increasing pH. chiswick 1978WebDimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility K Avgoustakis 2007, International Journal of Pharmaceutics graphtec b-513 manual

"WebThe solubility of theophylline in mixed solvents consisting of dioxane and water was determined at 25 +/- 0.1 degrees. The solubilities across this range of polar solvents were back-calculated using a technique involving an interaction energy term, W. " - Solubility of theophylline in water

Solubility of theophylline in water

Theophylline CAS 58-55-9 SCBT - Santa Cruz Biotechnology

WebSolubility: Theophylline is lightly soluble in water; soluble in hot water; sparingly soluble in alcohol, chloroform, and ether. It is freely soluble in alkali hydroxide solutions and in ammonia Sweetman (2002). Ionization Constant: Value: Salt: Conditions: Reference: Comments: pKa: 8.77: monohydrate: 25° O'Neil et al (2001) WebIncreasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica Zhouhua Wang,1,2 Bao Chen,1 Guilan Quan,1 Feng Li,1 Qiaoli Wu,1 Linghui Dian,1 Yixuan Dong,1 Ge Li,2 Chuanbin Wu1,21School of Pharmaceutical Sciences, 2Research and Development Center of …

Did you know?

WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was … WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was …

WebCommon-Ion Effect. The common-ion effect is a term that describes the decrease in solubility of an ionic compound when a salt that contains an ion that already exists in the chemical equilibrium is added to the mixture. This effect best be explained by Le Chatelier's principle.Imagine if the slightly soluble ionic compound calcium sulfate, CaSO 4, is added … WebIt is also moderately soluble in ethanol. Furthermore, it is soluble in alcohol (12.5 mg/ml), and chloroform (9.1 mg/ml), alkali hydroxides, ammonia, dilute hydrochloric or nitric acid, …

WebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was determined by a high performance liquid chromatography method at T = (288.15 to 328.15) K and atmospheric pressure. It was found that the solubility of theobromine, theophylline, … WebHowever, theophylline is only sparingly soluble in water and alcohol. The solubility of theophylline in water is 5.5 mg/mL, whereas in methanol and ethanol is 0.699 mg/mL and …

WebMar 1, 1983 · The solubilities of theophylline and theophylline hydrate as a function of temperature are determined in the temperature range 288–365K. The solubility as a …

WebThe solubility of theophylline in the resultant products was found to be three to five times higher than that of original theophylline. The solubilities of the products decreased with increasing drying temperature and rotation speed of the atomizer, which was interpreted in terms of the contents of ethylenediamine in the products. graphtec automatic cross cut optionsWebFeb 27, 2024 · Theophylline is a methylxanthine alkaloid that is a competitive inhibitor of phosphodiesterase (PDE; Ki = 100 μM). It is also a non-selective antagonist of adenosine A receptors (Ki = 14 μM for A1 and A2). Theophylline induces relaxation of feline bronchiole smooth muscle precontracted with acetylcholine (EC40 = 117 μM; EC80 = 208 μM). chis west little rockWebCaffeine, theobromine, and theophylline are all more fat soluble than they are water soluble. 5 mo. ago. Thank you! Does the extra methyl group on caffeine (as opposed to theophylline, theobromine and paraxanthine) not make a difference? Patrick26. The presence or absence of that methyl group does affect the solubilities, but they are still ... graphtec b-564WebAbstract - The solubility of caffeine in water, ethyl acetate, ethanol, carbon tetrachloride, methanol, chloroform, ... It belongs to the group of chemicals known as methylxanthines, which also includes the closely related chemicals theophylline and theobromine. In its pure form, caffeine occurs as odorless, white, fleecy masses, ... chis west midlandsWebAug 3, 2010 · The solubility of theophylline in water was modeled including hydrate formation (1:1) as well as polymorphic transitions of theophylline between the anhydrate … ch is what chemicalWebTheophylline is a cyclic phosphodiesterase inhibitor. It antagonizes Adenosine A Receptors and weakly inhibits alkaline phosphodiesterases and 5′-nucleotidase. ... Soluble in water (8.3 g/l) at 20° C, 0.1 M NaOH, 0.1 M HCl, ethanol (moderately), DMSO, alkali hydroxides, ammonia, dilute hyrochloric acid, nitric acid, ... chiswich fire fighter alan morehttp://elephantcare.org/resources/formulary/drug-index/aminophylline-theophylline/ graphtec acadp-20